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Further research, including long-term evaluation of sarcopenia in GLP-1RAs trials, development of standardized monitoring protocols and investigation of combined nutritional, exercise and pharmacologic strategies, is needed in order to prevent muscle loss while maximizing metabolic benefits under GLP-1RAs treatment

Plasma GLP-1 concentrations (pg/mL) were significantly decreased in cocaine-experienced rats versus yoked-saline controls following 21 days of self-administration (Fig 1B) and acute withdrawal (i.e., extinction day 1) (Fig 1C)

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